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Chem Impex International tert butyl 1 3 diisopropylisourea l glutamic acid di tert butyl ester
aReagents and conditions: (a) <t>tert-butyl-1,3-diisopropylisourea,</t> CH2Cl2, rt, 3 d; (b) carbonyldiimidazole, CH2Cl2, rt, 1 h; (c) l-glutamic acid di-tert-butyl ester, neat, 45 °C, 2 d; (d) TFA/CH2Cl2 (1/1), rt, 2 h; (e) N-succinimidyl-4-fluorobenzoate or N-succinimidyl-4-[18F]fluorobenzoate, Et3N, DMSO, rt, 2 h; (f) N-succinimidyl-4-iodobenzoate or N-succinimidyl-4-[125l]iodobenzoate, diisopropylethylamine, DMSO rt, 1 h.
Tert Butyl 1 3 Diisopropylisourea L Glutamic Acid Di Tert Butyl Ester, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aReagents and conditions: (a) tert-butyl-1,3-diisopropylisourea, CH2Cl2, rt, 3 d; (b) carbonyldiimidazole, CH2Cl2, rt, 1 h; (c) l-glutamic acid di-tert-butyl ester, neat, 45 °C, 2 d; (d) TFA/CH2Cl2 (1/1), rt, 2 h; (e) N-succinimidyl-4-fluorobenzoate or N-succinimidyl-4-[18F]fluorobenzoate, Et3N, DMSO, rt, 2 h; (f) N-succinimidyl-4-iodobenzoate or N-succinimidyl-4-[125l]iodobenzoate, diisopropylethylamine, DMSO rt, 1 h.

Journal: Journal of medicinal chemistry

Article Title: [ 18 F]Fluorobenzoyllysinepentanedioic Acid Carbamates: New Scaffolds for Positron Emission Tomography (PET) Imaging of Prostate-Specific Membrane Antigen (PSMA)

doi: 10.1021/acs.jmedchem.5b01268

Figure Lengend Snippet: aReagents and conditions: (a) tert-butyl-1,3-diisopropylisourea, CH2Cl2, rt, 3 d; (b) carbonyldiimidazole, CH2Cl2, rt, 1 h; (c) l-glutamic acid di-tert-butyl ester, neat, 45 °C, 2 d; (d) TFA/CH2Cl2 (1/1), rt, 2 h; (e) N-succinimidyl-4-fluorobenzoate or N-succinimidyl-4-[18F]fluorobenzoate, Et3N, DMSO, rt, 2 h; (f) N-succinimidyl-4-iodobenzoate or N-succinimidyl-4-[125l]iodobenzoate, diisopropylethylamine, DMSO rt, 1 h.

Article Snippet: General Procedures Solvents and chemicals purchased from commercial sources were of analytical grade or better and used without further purification. tert -Butyl-1,3-diisopropylisourea-L-glutamic acid di- tert -butyl ester, N ε -Boc-lysine- tert -butyl ester hydrochloride, 1-hydroxybenzotriazole monohydrate, and 2-(1 H -benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) were purchased from Chem Impex International Inc. (Wooddale, IL).

Techniques:

aReagents and conditions: (a) carbonyldiimidazole, CH2Cl2, rt, 1 h; (b) Mel, MeCN, 55 °C, 3 h; (c) N-Boc-lysine-tert-butyl ester hydrochloride, Et3N, DMSO, rt, overnight; (d) TFA/CH2Cl2 (1/1), rt, 2 h; (e) LiOH, THF/H2O (1/1), rt, 4 h; (f) N-succinimidyl-4-fluorobenzoate or N-succinimidyl-4-[18F]fluorobenzoate, Et3N, DMSO, rt, 2 h; (g) N-succinimidyl-4-[125I]iodobenzoate or N-succinimidyl-4-iodobenzoate, diisopropylethylamine, DMSO, rt, 1 h; (h) N-succinimidyl 4-bromo-2-fluorobenzoate, Et3N, DMSO, rt, 2 h; (i) N-succinimidyl 4-iodo-2-fluorobenzoate, Et3N, DMSO, rt, 2 h.

Journal: Journal of medicinal chemistry

Article Title: [ 18 F]Fluorobenzoyllysinepentanedioic Acid Carbamates: New Scaffolds for Positron Emission Tomography (PET) Imaging of Prostate-Specific Membrane Antigen (PSMA)

doi: 10.1021/acs.jmedchem.5b01268

Figure Lengend Snippet: aReagents and conditions: (a) carbonyldiimidazole, CH2Cl2, rt, 1 h; (b) Mel, MeCN, 55 °C, 3 h; (c) N-Boc-lysine-tert-butyl ester hydrochloride, Et3N, DMSO, rt, overnight; (d) TFA/CH2Cl2 (1/1), rt, 2 h; (e) LiOH, THF/H2O (1/1), rt, 4 h; (f) N-succinimidyl-4-fluorobenzoate or N-succinimidyl-4-[18F]fluorobenzoate, Et3N, DMSO, rt, 2 h; (g) N-succinimidyl-4-[125I]iodobenzoate or N-succinimidyl-4-iodobenzoate, diisopropylethylamine, DMSO, rt, 1 h; (h) N-succinimidyl 4-bromo-2-fluorobenzoate, Et3N, DMSO, rt, 2 h; (i) N-succinimidyl 4-iodo-2-fluorobenzoate, Et3N, DMSO, rt, 2 h.

Article Snippet: General Procedures Solvents and chemicals purchased from commercial sources were of analytical grade or better and used without further purification. tert -Butyl-1,3-diisopropylisourea-L-glutamic acid di- tert -butyl ester, N ε -Boc-lysine- tert -butyl ester hydrochloride, 1-hydroxybenzotriazole monohydrate, and 2-(1 H -benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) were purchased from Chem Impex International Inc. (Wooddale, IL).

Techniques: